Interna Medicina Vrhovac Pdf Dow: The Ultimate Resource for Medical Students and Professionals

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To monitor the dynamics of the disease (both progression and response to therapy), TTM score (described in clinical stage) is very convenient because it is the only clinical system that is based on a continuous, quantitative parameter that is easy to apply and validated in thousands of patients in various international clinical trials. To estimate the doubling time (DT), it is more reliable than just the number of lymphocytes because it can compensate for changes in the distribution of the tumor mass occurrence after the administration of corticosteroids or TKIs, when there may be an increase in the number of leukocytes while reducing the nodes or spleen. For this reason, the NCI/iwCLL criteria have recently been amended, but are still suboptimal for monitoring disease response (23, 112), while the TTM scoring system is much better for measuring redistribution of clonal cells among compartments (30, 113).

Interna Medicina Vrhovac Pdf Dow

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